In Zombie Highway 2, players navigate a randomly generated road while driving a vehicle, aiming to survive against waves of zombies. The core mechanics involve tilting the device to steer and tapping to shoot, allowing players to smash or shoot zombies that latch onto their car.

The storyline of Zombie Highway 2 revolves around a post-apocalyptic scenario where players must fend off relentless zombie attacks while trying to escape down a treacherous highway. The objective is to survive as long as possible while completing various challenges.

Zombie Highway 2 stands out with its unique combination of racing and shooting mechanics, a diverse array of vehicles and weapons, and daily challenges that keep gameplay fresh and engaging. The game also features a social aspect, allowing players to compete against friends' scores.