In Postal Babes, players engage in hack-and-slash combat mechanics, utilizing a variety of weapons such as baseball bats and knives, while also having the option to pick up firearms for ranged attacks. The intuitive control system allows for quick and fluid gameplay, enabling players to execute combos and take down enemies effectively.

The storyline of Postal Babes revolves around a group of female characters who must infiltrate a university overrun by maniacs to rescue first-year student hostages. As they navigate through the campus, players encounter various challenges and enemies that require strategic combat.

Postal Babes stands out with its blend of action and humor, featuring strong female leads who embody empowerment while delivering a unique take on the shooter genre. The game's vibrant art style and engaging gameplay mechanics contribute to its distinct identity within the Postal universe.