In Mist Train Girls, players collect and manage a harem of military girls, utilizing a deep turn-based battle system that allows for various strategies and tactics in combat. Players can customize their teams and engage in battles against various foes to progress through the game.

The storyline of Mist Train Girls revolves around the continent of Iris Cloud, which is enveloped in a mysterious mist. Players embark on a quest to rid the land of this wicked Mist, uncovering secrets and forming bonds with their characters along the way.

Mist Train Girls stands out with its fully-voiced narrative and character interactions, enhancing the immersive experience while providing players with a rich, story-driven RPG adventure.