In Melotube, players engage in rhythm-based gameplay by tapping along to the beat of any YouTube video, transforming the viewing experience into an interactive challenge. The game utilizes a simple yet effective control scheme that encourages players to stay in sync with the music.

The storyline of Melotube is minimal, focusing primarily on the player's journey to master rhythm challenges across various genres and styles of music available on YouTube. Players can select any video, making each session a personalized adventure.

Melotube stands out with its innovative integration of YouTube content, allowing users to play rhythm games with virtually any song or video, thus offering endless replayability and a diverse range of musical experiences.