In Lobotomy Corporation, players assume the role of an administrator tasked with managing "Abnormalities," which are monstrous entities that generate energy. Players must strategically assign employees to interact with these creatures while ensuring their safety and maximizing energy extraction.

The storyline revolves around a newly established energy company that claims to harness infinite entropy through the containment of these Abnormalities. As players progress, they uncover the dark realities of the facility and the true nature of the creatures they manage.

Lobotomy Corporation stands out with its intricate mechanics that require players to balance employee safety, energy production, and the unpredictable behavior of Abnormalities, creating a tense and engaging gameplay experience.