In Lethal Honor, players engage in fast-paced melee combat against eldritch creatures while utilizing powerful abilities and unique artifacts. The gameplay emphasizes strategic combinations and adapting playstyles to survive the punishing challenges presented.

The storyline unfolds on Wolf Island, where players become part of a secret organization investigating paranormal events. As players progress through the game, they uncover dark secrets and the fates of Lost and Key Agents, each with their own narratives.

Lethal Honor stands out with its integration of hand-drawn comic panels that immerse players in a gritty, dark narrative, alongside procedurally generated runs that keep the gameplay fresh and engaging.