In Isolation One, players navigate the vast and eerie environment of the Transporter P18 spaceship, solving intricate puzzles while battling various threats. The core mechanics emphasize exploration, resource management, and strategic decision-making to survive the challenges presented by the game.

The storyline of Isolation One revolves around a crew's mysterious disappearance and the player's quest to uncover the truth behind the events that transpired aboard the ship. As players delve deeper into the narrative, they encounter chilling revelations that intertwine science fiction with horror elements.

Isolation One stands out with its atmospheric design and a unique blend of action and puzzle-solving, creating a tense experience that keeps players engaged as they unravel the ship's dark secrets.