In Factorio, players control a single character on an alien planet, gathering resources, crafting items, and building complex factories to automate production. The gameplay emphasizes resource management and strategic planning, as players must efficiently mine materials and construct machinery to progress.

The storyline of Factorio follows an astronaut stranded on a hostile planet, tasked with surviving and building a rocket to escape. As the player develops their factory, they must contend with the planet's native inhabitants, who perceive the astronaut as a threat.

Factorio stands out with its intricate automation systems and the ability to create vast, interconnected factories. The game also incorporates tower defense elements, requiring players to build defenses against aggressive alien creatures while managing their industrial operations.