In Epyx Rogue, players navigate the Dungeons of Doom, engaging in turn-based combat against various monsters while collecting treasure and items to aid in their quest for the Amulet of Yendor. The gameplay emphasizes strategic decision-making and resource management, as players must carefully plan their moves to survive.

The storyline of Epyx Rogue revolves around the player's journey through treacherous dungeons filled with enemies and traps, ultimately aiming to retrieve the powerful Amulet of Yendor, a task fraught with danger and uncertainty.

Epyx Rogue stands out with its nostalgic pixel-art graphics and optional CRT filters that enhance the retro aesthetic, alongside a customizable soundtrack that can be toggled, allowing players to tailor their gaming experience while remaining faithful to the original's charm.