In Double Sequence, players manipulate blocks of genetic code to match colors and decode the Q-Virus DNA. The gameplay involves sliding and shifting these blocks to create connections, with increasing complexity as players progress through various levels.

The storyline of Double Sequence revolves around a catastrophic invasion of Q-Viruses that threaten to exterminate all life in the universe. Players take on the role of a hero tasked with cracking the Q-Virus code to save civilization from annihilation.

Double Sequence stands out with its innovative use of the Nintendo DS stylus for gameplay, allowing for intuitive control and interaction. Additionally, the game features over 30 unique planets to explore and the ability for players to create and share their own Q-Virus strands via WiFi, enhancing the game's replayability and community engagement.