In Doom 3: The Lost Mission, players navigate through a series of intense environments, utilizing a variety of weapons and tools to combat demonic foes. The gameplay emphasizes both exploration and combat, with a focus on atmospheric horror elements that are characteristic of the Doom series.

The storyline of Doom 3: The Lost Mission follows a marine who is tasked with uncovering the mysteries behind the UAC's experiments on Mars, facing off against the forces of Hell that have been unleashed. Players must survive and unravel the narrative while battling through hordes of enemies.

Doom 3: The Lost Mission stands out with its enhanced graphics and refined gameplay mechanics, offering a nostalgic yet updated experience for fans of the franchise. The game also features new levels and challenges that expand upon the original Doom 3 narrative.