In Doctor Fizzwizzle's Animal Rescue, players bounce bubbles to rescue hungry animals while navigating through over 180 levels of brick-busting action. The core mechanics involve strategic bubble placement and timing to clear obstacles and collect coins.

The storyline of Doctor Fizzwizzle's Animal Rescue revolves around the mysterious disappearance of people from the islands, leaving Doctor Fizzwizzle to uncover the truth and care for the abandoned animals. Players must solve the mystery while ensuring the animals are fed and safe.

Doctor Fizzwizzle's Animal Rescue stands out with its compatibility with the Wii Balance Board, allowing for an interactive gameplay experience, and features a special kids' mode that includes fun animal quizzes to engage younger players.