In Cannibal Crossing, players explore a randomly generated town, scavenging for resources, building bases, and fighting off hordes of cannibalistic foes. The gameplay emphasizes both solo and cooperative experiences, allowing players to team up with friends or face the challenges alone.

The storyline of Cannibal Crossing revolves around surviving in a town overrun by mutant cannibals while searching for a way to escape. Players encounter various threats, including bandits and beasts, as they navigate the dangers of the environment.

Cannibal Crossing stands out with its randomly generated open world, diverse character selection, and the ability to rescue other survivors, enhancing the gameplay experience. The game also features intense enemy hordes and unique invasion events, adding layers of strategy and excitement to each playthrough.