In Bio Menace, players control Snake Logan, a weapons expert who battles through levels filled with mutants and robotic enemies, utilizing a variety of weapons including a high-powered machine gun and grenades. The gameplay emphasizes fast-paced action and platforming mechanics, requiring players to navigate through challenging environments while defeating foes.

The storyline of Bio Menace revolves around Snake Logan's mission to stop the villain Dr. Mangle, who is responsible for the chaos and destruction in the city of Metro. Players must infiltrate Mangle's fortress and confront him to restore peace.

Bio Menace stands out with its groundbreaking animation and design, featuring a diverse array of fantastically animated creatures and formidable bosses. The game also includes hidden areas, multiple skill levels, and a variety of weapons, enhancing the overall gameplay experience.