In Best of Tests DS, players engage in a series of challenges that test their logic, observation, memory, and speed of perception across three gaming modes: Training, Memory, and Tests. The game adapts to the player's skill level, offering personalized challenges that evolve over time.

The storyline of Best of Tests DS revolves around the concept of measuring and enhancing one's intelligence quotient (I.Q.) through a variety of interactive tests and puzzles. Players are encouraged to improve their cognitive abilities while enjoying the gameplay experience.

Best of Tests DS stands out with its extensive range of several hundred unique questions and challenges, along with a humorous presentation of results. The game features incremental difficulty levels, ensuring that players remain engaged and continuously challenged as they progress.