In Artifact, players engage in strategic gameplay by constructing decks from a pool of over 280 cards, including 44 heroes, and competing in matches that involve managing resources and deploying units across three lanes. The game emphasizes tactical decision-making and resource management.

The storyline of Artifact is set in the Dota universe, where players take on the role of powerful heroes battling against each other, with the ultimate goal of destroying the opponent's Ancient. The narrative unfolds through the interactions and conflicts between these iconic characters.

Artifact stands out with its innovative mechanics, such as the three-lane system that adds depth to strategy and gameplay, as well as the ability to buy and sell cards on the Steam Community Marketplace, enhancing the game's economic aspect.