In Anon’s Neko Waifus, players take on the role of Anon, navigating various scenarios to impress different neko girls. The core mechanics involve engaging in conversations, rolling dice to determine outcomes, and collecting unique cards that reflect the characters' reactions to the player's choices.

The storyline follows Anon as he encounters various neko girls, starting with Tami, who seeks help moving into her new flat. This chance meeting leads to a series of romantic adventures filled with humor and unexpected connections.

Anon’s Neko Waifus stands out with its vibrant art style, voiced dialogue, and a collection system that encourages players to gather over 60 collectible cards, each representing different interactions and outcomes in the game.