In ANNO: Mutationem, players control Ann, a skilled combatant navigating a vibrant metropolis filled with various challenges. The gameplay features seamless transitions between 2D action-platforming and 3D exploration, allowing players to interact with the environment and its inhabitants in diverse ways.

The storyline follows Ann as she embarks on a personal mission to locate her missing brother, uncovering dark secrets within a world dominated by mega-corporations and bizarre creatures. Alongside her hyper hacker sidekick Ayane, players delve into a narrative rich with intrigue and unexpected twists.

ANNO: Mutationem stands out with its unique 2D-to-3D gameplay mechanics and a richly detailed cyberpunk world, offering players the freedom to explore, engage in side quests, and customize their combat experience through crafting and upgrades.